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Skin rashes, which are the only sign of Kirle's disease, can be located on various parts of the body, so it is not necessary to talk about the typical localization of the pathological process. Distinctive features of changes in this pathology are: the appearance of the first signs in the armpits. This phenomenon is observed often, but not in all 100% of cases; often changes are localized on the extensor surfaces of the elbow and knee joints, the outer surface of the lower leg and forearm; in some cases, the disease is disseminated, changes are localized on the limbs, scalp, face and other parts of the body; rashes in Kirle's disease are never observed on the palmar surface of the hand and the plantar surface of the foot.

It cannot be said that Kirle's disease has any peculiarities when localized on the face, however, changes are quite often found on the scalp and face, they are a great aesthetic disadvantage and cause psychological suffering. Since rashes are the only manifestation of the disease, and there are no subjective sensations, patients often seek help precisely when changes are localized on the face or other open areas of the body. The psychological problems caused by Kirle's disease are most pronounced precisely in the presence of changes on the face; in all other senses, this localization of the disease does not differ in any way from all other forms of this pathology.

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To date, the true causes of diflucan pills have not been established, which is why it is called essential (idiopathic) follicular hyperkeratosis. Among the factors that can contribute to the appearance of the disease, it is worth mentioning: hereditary predisposition (the disease is more often observed in children whose parents suffered from such a pathology); hormonal disorders (diabetes mellitus, impaired glucose tolerance); liver damage (hepatitis of various nature, hepatosis); diabetic nephropathy; a certain role is given to a lack of vitamin A (it can also be the cause of the development of leukoplakia on the mucous membranes and atrophic changes in the skin).
Symptoms and manifestations of Kirle's disease. A characteristic feature of the clinical picture in Kirle's disease is the complete absence of any subjective changes. Itching, burning and other unpleasant symptoms in the area of ​​​​rashes are absent, fever is not observed, the general condition does not suffer in any way.
The manifestation of Kirle's disease in the form of fluconazole (in the form of a pinhead) The tubercles tend to merge, resulting in a semblance of a wart. Often the disease is detected at this stage, and it is quite difficult to make a differential diagnosis with warts. A distinctive feature is that the horny layers are easily removed, but after that a weeping surface remains.
Kirle disease in the form of a wart. This distinguishes Kirle's essential keratosis from lichen pilaris, in which the horny scales are removed with ease, leaving no traces behind. The disease differs from lichen planus by the absence of primary red rashes (a yellow tubercle immediately appears) and the absence of subjective manifestations (pronounced skin itching).
Therapy for the diagnosis of Kerle's disease should be comprehensive, systematic and long-term. Treatment is based on: long-term intake of vitamin A capsules; the use of local retinoic ointments; the use fluconazole pills ointments; ultraviolet irradiation of lesions; a comprehensive examination to determine the presence of diseases that can contribute to Kirle's disease (endocrine pathology, including diabetes, liver and kidney damage).
Surgical methods are used in cases where the growths are too pronounced or localized on the face, as well as when long-term therapy is ineffective. To remove formations, they can be excised, cryotherapy with liquid nitrogen is used, diathermocoagulation is often used. Treatment with folk remedies.
Despite the fact that Kirle's disease is a rather rare dermatosis, there are some folk remedies for rashes characteristic of essential follicular hyperkeratosis, among them should be mentioned: the use of decoctions or pomace from sea buckthorn, which should be applied to the skin lesions; the use of grated beets (applied topically); the use diflucan in grated form on the site of the lesion or in the form of carrot juice, from which lotions are made.
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